Not all randomized trials are equal.
نویسنده
چکیده
he study by Beanlands et al. (1) in this issue of the Journal s a multicenter, randomized trial in 430 patients with oronary artery disease (CAD) and left ventricular ejection raction 35% to determine whether a management stratgy that included F-18-fluorodeoxyglucose (FDG) positron mission tomography (PET) imaging to guide revascularzation improved clinical outcomes compared with standard are where FDG PET was not available. On the basis of trict statistical analysis, the results show that PET FDG maging for guiding revascularization did not improve utcomes compared with standard management without DG PET.
منابع مشابه
O-25: Single and Dual Embryo Transfer, HowFar We Are?
Background: To explore and compare the dual embryo transfer DET with single embryo transfer SET weather electively or not, in more viewpoints like financially, and scientifically and finding out which of these policies may give better outcome by analyzing both in a neutral broad spectrum manner. Materials and Methods: A computerized comprehensive search studies ended in finding of 62 articles o...
متن کاملImportant considerations in calculating and reporting of sample size in randomized controlled trials
Background: The calculation of the sample size is one of the most important steps in designing a randomized controlled trial. The purpose of this study is drawing the attention of researchers to the importance of calculating and reporting the sample size in randomized controlled trials. Methods: We reviewed related literature and guidelines and discussed some important issues in s...
متن کاملEfficacy of Prasaplai for Treatment of Primary Dysmenorrhea: a Meta-Analysis
Prasaplai is used in Thai traditional medicine for treatment of primary dysmenorrhea; however, clinical evidence is limited regarding the efficacy of Prasaplai for primary dysmenorrheal outcomes. This study has constituted a systematic review and meta-analysis to evaluate Prasaplai as an effective treatment for primary dysmenorrhea. Randomized controlled trials were retrieved and identified thr...
متن کاملA Systematic Review and Meta-Analysis of Randomized Controlled Trials Comparing the Safety of Dapagliflozin in Type 1 Diabetes Patients
Background and Purpose: The dapagliflozin’s safety profile in insulin-treated adult type-1 diabetes mellites (T1DM) patients remains poorly explored. Therefore, this systematic review and meta-analysis compared the risk of all-cause side effects, study discontinuation of participants due to side effects, urinary tract infection (UTI), diabetic ketoacidosis, and hypoglycemia between dapagliflozi...
متن کاملComparing Methods of Tuning Adaptively Randomized Trials
The simplest Bayesian adaptive randomization scheme is to randomize patients to a treatment with probability equal to the probability p that the treatment is better. We examine three variations on adaptive randomization which are used to compromise between this scheme and equal randomization. The first variation is to apply a power transformation to p to obtain randomization probabilities. The ...
متن کاملSample Size Calculation of Exact Tests for the Weak Causal Null Hypothesis in Randomized Trials with a Binary Outcome
The main purpose in many randomized trials is to make an inference about the average causal effect of a treatment. Therefore, on a binary outcome, the null hypothesis for the hypothesis test should be that the causal risks are equal in the two groups. This null hypothesis is referred to as the weak causal null hypothesis. Nevertheless, at present, hypothesis tests applied in actual randomized t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of the American College of Cardiology
دوره 50 20 شماره
صفحات -
تاریخ انتشار 2007